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| H (Match allé) | Olimpia | - | Real España | 2:0 (1:0) | ||
| R (match retour) | Real España | - | Olimpia | 0:1 (0:0) | ||
| H (Match allé): 19.12.2021 23:00 | R (match retour): 24.12.2021 02:00 | vainqueur: Olimpia | ||||
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| H (Match allé) | Olimpia | - | Real España | 2:0 (1:0) | ||
| R (match retour) | Real España | - | Olimpia | 0:1 (0:0) | ||
| H (Match allé): 19.12.2021 23:00 | R (match retour): 24.12.2021 02:00 | vainqueur: Olimpia | ||||
