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| H (Match allé) | Motagua | - | Real España | 1:0 (1:0) | ||
| R (match retour) | Real España | - | Motagua | 6:7 (0:0, 1:0, 1:0) tab | ||
| H (Match allé): 10.05.2021 01:00 | R (match retour): 13.05.2021 02:00 | vainqueur: Motagua | ||||
| H (Match allé) | Honduras Progreso | - | Olimpia | 0:0 (0:0) | ||
| R (match retour) | Olimpia | - | Honduras Progreso | 7:0 (3:0) | ||
| H (Match allé): 10.05.2021 03:00 | R (match retour): 13.05.2021 03:00 | vainqueur: Olimpia | ||||
