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| 27.04.2022 | 14:30 | PAE Chania | - | OFI Ierapetra | 2:0 (1:0) | |
| 14:30 | Diagoras FC | - | GS Kallithea | 0:0 (0:0) | ||
| 14:30 | Asteras Vlachioti | - | AO Egaleo | 2:1 (0:1) | ||
| 14:30 | Ergotelis | - | Irodotos | 0:1 (0:0) | ||
| 14:30 | AE Karaiskakis | - | Levadiakos | 0:3 (0:2) | ||
| 14:30 | Panathinaikos II | - | AS Rhodos | 3:0 | ||
| 14:30 | Kalamata | - | AO Episkopi | 5:0 (3:0) | ||
| 14:30 | AEK Athen II | - | AE Kifisias | 2:2 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Levadiakos | 31 | 21 | 6 | 4 | 67:19 | 48 | 69 |
| 2 |
|
GS Kallithea | 31 | 18 | 8 | 5 | 43:18 | 25 | 62 |
| 3 |
|
Kalamata | 31 | 18 | 7 | 6 | 49:19 | 30 | 58 |
| 4 |
|
PAE Chania | 31 | 14 | 13 | 4 | 45:22 | 23 | 55 |
| 5 |
|
AEK Athen II | 32 | 14 | 10 | 8 | 38:27 | 11 | 52 |
| 6 |
|
AE Kifisias | 31 | 15 | 5 | 11 | 36:29 | 7 | 50 |
| 7 |
|
AO Egaleo | 31 | 13 | 7 | 11 | 30:29 | 1 | 46 |
| 8 |
|
AO Episkopi | 31 | 12 | 9 | 10 | 24:23 | 1 | 45 |
| 9 |
|
Ergotelis | 31 | 11 | 7 | 13 | 23:31 | -8 | 40 |
| 10 |
|
Asteras Vlachioti | 31 | 9 | 8 | 14 | 31:36 | -5 | 35 |
| 11 |
|
Panathinaikos II | 31 | 9 | 7 | 15 | 28:37 | -9 | 34 |
| 12 |
|
Irodotos | 31 | 9 | 7 | 15 | 27:41 | -14 | 34 |
| 13 |
|
OFI Ierapetra | 31 | 9 | 7 | 15 | 38:48 | -10 | 34 |
| 14 |
|
Diagoras FC | 31 | 8 | 9 | 14 | 20:35 | -15 | 33 |
| 15 |
|
AE Karaiskakis | 31 | 7 | 8 | 16 | 24:47 | -23 | 29 |
| 16 |
|
AS Rhodos | 31 | 7 | 6 | 18 | 24:48 | -24 | 12 |
| 17 |
|
APS Zakynthos | 31 | 5 | 6 | 20 | 18:56 | -38 | 12 |
| Play-off | |
| Relégation | |
| Relégation |
