 |
 |
|
|
| 22.01.2022 | 13:45 | Almopos Arideas | - | Olympiakos Piraeus II | 3:0 (1:0) | |
| 13:45 | Niki Volou FC | - | Apollon Lárissa | 0:2 (0:1) | ||
| 16:00 | Xanthi FC | - | Veria FC | 0:3 (0:1) | ||
| 23.01.2022 | 13:45 | Pierikos Katerini | - | Apollon Pontou | 1:0 (1:0) | |
| 13:45 | Thesprotos | - | AEP Iraklis FC | 1:5 (0:3) | ||
| 13:45 | AO Kavala | - | Panserraikos | 2:2 (0:0) | ||
| 13:45 | Olympiakos Volou | - | AE Lárissa | 1:2 (0:1) | ||
| 17.03.2022 | 14:00 | PAOK Saloniki II | - | AO Trikala | 3:0 (2:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Veria FC | 14 | 9 | 3 | 2 | 33:13 | 20 | 30 |
| 2 |
|
AE Lárissa | 14 | 8 | 5 | 1 | 20:5 | 15 | 29 |
| 3 |
|
Anagennisi Karditsa | 14 | 8 | 3 | 3 | 25:12 | 13 | 27 |
| 4 |
|
Xanthi FC | 14 | 7 | 4 | 3 | 20:10 | 10 | 25 |
| 5 |
|
AEP Iraklis FC | 14 | 4 | 9 | 1 | 14:9 | 5 | 21 |
| 6 |
|
Niki Volou FC | 14 | 5 | 5 | 4 | 19:10 | 9 | 20 |
| 7 |
|
Olympiakos Piraeus II | 14 | 4 | 7 | 3 | 15:15 | 0 | 19 |
| 8 |
|
Almopos Arideas | 14 | 5 | 3 | 6 | 18:14 | 4 | 18 |
| 9 |
|
Thesprotos | 14 | 5 | 3 | 6 | 19:16 | 3 | 18 |
| 10 |
|
PAOK Saloniki II | 14 | 4 | 6 | 4 | 18:16 | 2 | 18 |
| 11 |
|
AO Trikala | 15 | 4 | 4 | 7 | 13:24 | -11 | 16 |
| 12 |
|
Pierikos Katerini | 15 | 3 | 6 | 6 | 16:18 | -2 | 15 |
| 13 |
|
Olympiakos Volou | 14 | 4 | 3 | 7 | 18:22 | -4 | 15 |
| 14 |
|
Apollon Pontou | 14 | 3 | 4 | 7 | 18:23 | -5 | 13 |
| 15 |
|
Panserraikos | 14 | 2 | 7 | 5 | 15:21 | -6 | 13 |
| 16 |
|
Apollon Lárissa | 14 | 2 | 6 | 6 | 11:19 | -8 | 12 |
| 17 |
|
AO Kavala | 14 | 2 | 4 | 8 | 9:54 | -45 | 10 |
| Play-off | |
| Relégation |
