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| 05.02.2022 | 16:00 | AS Monaco (CFA) | - | Louhans-Cuiseaux | 1:1 (0:0) | |
| 16:00 | GFA Rumilly Vallières | - | Olympique Lyon (CFA) | 0:0 (0:0) | ||
| 17:00 | GOAL FC | - | Jura Sud | 2:0 (1:0) | ||
| 17:00 | Lyon-La Duchère | - | Hyères FC | 1:1 (1:0) | ||
| 17:00 | SC Toulon | - | Aubagne FC | 0:0 (0:0) | ||
| 18:00 | Étoile FC | - | Olympique Marseille (CFA) | 1:1 (0:0) | ||
| 18:00 | FC Martigues | - | RC Grasse | 2:0 (2:0) | ||
| 18:00 | AS Saint-Priest | - | Marignane Gignac FC | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
GOAL FC | 17 | 10 | 5 | 2 | 32:11 | 21 | 35 |
| 2 |
|
Aubagne FC | 17 | 8 | 6 | 3 | 24:16 | 8 | 30 |
| 3 |
|
RC Grasse | 17 | 8 | 5 | 4 | 17:13 | 4 | 29 |
| 4 |
|
Louhans-Cuiseaux | 17 | 7 | 7 | 3 | 22:15 | 7 | 28 |
| 5 |
|
FC Martigues | 17 | 7 | 7 | 3 | 19:15 | 4 | 28 |
| 6 |
|
Olympique Lyon (CFA) | 17 | 7 | 6 | 4 | 20:18 | 2 | 27 |
| 7 |
|
Marignane Gignac FC | 17 | 7 | 4 | 6 | 19:16 | 3 | 25 |
| 8 |
|
Jura Sud | 17 | 6 | 5 | 6 | 22:24 | -2 | 23 |
| 9 |
|
Étoile FC | 17 | 5 | 7 | 5 | 16:15 | 1 | 22 |
| 10 |
|
AS Monaco (CFA) | 17 | 5 | 5 | 7 | 16:20 | -4 | 20 |
| 11 |
|
Lyon-La Duchère | 17 | 4 | 6 | 7 | 16:21 | -5 | 18 |
| 12 |
|
SC Toulon | 17 | 3 | 9 | 5 | 13:14 | -1 | 18 |
| 13 |
|
Hyères FC | 17 | 3 | 8 | 6 | 15:19 | -4 | 17 |
| 14 |
|
GFA Rumilly Vallières | 17 | 4 | 5 | 8 | 13:21 | -8 | 17 |
| 15 |
|
AS Saint-Priest | 17 | 4 | 2 | 11 | 18:27 | -9 | 14 |
| 16 |
|
Olympique Marseille (CFA) | 17 | 3 | 3 | 11 | 12:29 | -17 | 12 |
| Promotion | |
| Relégation |
