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| 10.01.2016 | 11:30 | Sevilla Atlético | - | UCAM Murcia CF | 1:0 (0:0) | |
| 11:30 | UD Almería B | - | FC Jumilla | 3:1 (1:0) | ||
| 12:00 | La Hoya Lorca CF | - | CF Villanovense | 0:5 (0:1) | ||
| 12:00 | Real Murcia | - | Marbella FC | 0:0 (0:0) | ||
| 12:00 | UD Melilla | - | Algeciras CF | 1:2 (0:2) | ||
| 12:00 | CD San Roque | - | Granada CF B | 1:1 (0:1) | ||
| 17:00 | Linares Deportivo | - | FC Cartagena | 0:0 (0:0) | ||
| 17:00 | RB Linense | - | Real Jaén | 0:1 (0:1) | ||
| 17:00 | Mérida AD | - | Real Betis B | 0:1 (0:1) | ||
| 18:00 | Cádiz CF | - | Recreativo Huelva | 2:1 (2:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Real Murcia | 20 | 13 | 4 | 3 | 31:13 | 18 | 43 |
| 2 |
|
Sevilla Atlético | 20 | 10 | 9 | 1 | 25:13 | 12 | 39 |
| 3 |
|
Cádiz CF | 20 | 10 | 8 | 2 | 29:12 | 17 | 38 |
| 4 |
|
UCAM Murcia CF | 20 | 11 | 5 | 4 | 25:12 | 13 | 38 |
| 5 |
|
Real Jaén | 20 | 10 | 2 | 8 | 30:16 | 14 | 32 |
| 6 |
|
Granada CF B | 20 | 7 | 9 | 4 | 25:17 | 8 | 30 |
| 7 |
|
Algeciras CF | 20 | 8 | 4 | 8 | 16:23 | -7 | 28 |
| 8 |
|
Marbella FC | 20 | 6 | 10 | 4 | 27:19 | 8 | 28 |
| 9 |
|
FC Cartagena | 20 | 6 | 9 | 5 | 21:19 | 2 | 27 |
| 10 |
|
La Hoya Lorca CF | 20 | 6 | 8 | 6 | 16:23 | -7 | 26 |
| 11 |
|
Mérida AD | 20 | 5 | 9 | 6 | 17:22 | -5 | 24 |
| 12 |
|
CD San Roque | 20 | 3 | 14 | 3 | 29:30 | -1 | 23 |
| 13 |
|
Linares Deportivo | 20 | 4 | 11 | 5 | 19:23 | -4 | 23 |
| 14 |
|
CF Villanovense | 20 | 5 | 6 | 9 | 24:29 | -5 | 21 |
| 15 |
|
Recreativo Huelva | 20 | 5 | 6 | 9 | 14:23 | -9 | 21 |
| 16 |
|
RB Linense | 20 | 5 | 5 | 10 | 22:26 | -4 | 20 |
| 17 |
|
Real Betis B | 20 | 5 | 4 | 11 | 19:28 | -9 | 19 |
| 18 |
|
UD Almería B | 20 | 4 | 5 | 11 | 15:26 | -11 | 17 |
| 19 |
|
FC Jumilla | 20 | 4 | 5 | 11 | 16:36 | -20 | 17 |
| 20 |
|
UD Melilla | 20 | 3 | 7 | 10 | 15:25 | -10 | 16 |
| Play-off | |
| Play-off | |
| Relégation | |
| Relégation |
