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| 21.01.2022 | 21:00 | Espanyol Barcelona | - | Real Betis | 1:4 (1:2) | |
| 22.01.2022 | 14:00 | Levante UD | - | Cádiz CF | 0:2 (0:1) | |
| 16:15 | Villarreal CF | - | RCD Mallorca | 3:0 (2:0) | ||
| 18:30 | Sevilla FC | - | RC Celta | 2:2 (0:2) | ||
| 21:00 | Atlético Madrid | - | Valencia CF | 3:2 (0:2) | ||
| 23.01.2022 | 14:00 | Granada CF | - | CA Osasuna | 0:2 (0:0) | |
| 16:15 | Real Madrid | - | Elche CF | 2:2 (0:1) | ||
| 18:30 | Rayo Vallecano | - | Athletic Bilbao | 0:1 (0:1) | ||
| 18:30 | Real Sociedad | - | Getafe CF | 0:0 (0:0) | ||
| 21:00 | CD Alavés | - | FC Barcelona | 0:1 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Real Madrid | 22 | 15 | 5 | 2 | 47:20 | 27 | 50 |
| 2 |
|
Sevilla FC | 22 | 13 | 7 | 2 | 34:16 | 18 | 46 |
| 3 |
|
Real Betis | 22 | 12 | 4 | 6 | 41:25 | 16 | 40 |
| 4 |
|
Real Sociedad | 22 | 10 | 7 | 5 | 24:21 | 3 | 37 |
| 5 |
|
Atlético Madrid | 22 | 10 | 6 | 6 | 36:27 | 9 | 36 |
| 6 |
|
FC Barcelona | 22 | 9 | 8 | 5 | 32:24 | 8 | 35 |
| 7 |
|
Rayo Vallecano | 22 | 10 | 4 | 8 | 28:22 | 6 | 34 |
| 8 |
|
Villarreal CF | 22 | 8 | 8 | 6 | 36:23 | 13 | 32 |
| 9 |
|
Athletic Bilbao | 22 | 7 | 10 | 5 | 21:17 | 4 | 31 |
| 10 |
|
Valencia CF | 22 | 7 | 8 | 7 | 35:36 | -1 | 29 |
| 11 |
|
CA Osasuna | 22 | 7 | 7 | 8 | 22:27 | -5 | 28 |
| 12 |
|
RC Celta | 22 | 7 | 6 | 9 | 26:25 | 1 | 27 |
| 13 |
|
Espanyol Barcelona | 22 | 7 | 6 | 9 | 26:30 | -4 | 27 |
| 14 |
|
Granada CF | 22 | 5 | 9 | 8 | 26:33 | -7 | 24 |
| 15 |
|
Elche CF | 22 | 5 | 8 | 9 | 23:30 | -7 | 23 |
| 16 |
|
Getafe CF | 22 | 5 | 7 | 10 | 17:23 | -6 | 22 |
| 17 |
|
RCD Mallorca | 22 | 4 | 8 | 10 | 17:35 | -18 | 20 |
| 18 |
|
Cádiz CF | 22 | 3 | 9 | 10 | 19:36 | -17 | 18 |
| 19 |
|
CD Alavés | 22 | 4 | 5 | 13 | 16:35 | -19 | 17 |
| 20 |
|
Levante UD | 22 | 2 | 8 | 12 | 22:43 | -21 | 14 |
| Champions League | |
| Europa League | |
| Relégation |
