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| H (Match allé) | Paraná Clube | - | Red Bull Bragantino | 0:1 (0:1) | ||
| R (match retour) | Red Bull Bragantino | - | Paraná Clube | 2:1 (0:0) | ||
| H (Match allé): 25.08.2022 20:00 | R (match retour): 01.09.2022 00:00 | vainqueur: Red Bull Bragantino | ||||
| H (Match allé) | Fortaleza | - | Fluminense - RJ | 2:2 (1:2) | ||
| R (match retour) | Fluminense - RJ | - | Fortaleza | 1:0 (0:0) | ||
| H (Match allé): 25.08.2022 20:00 | R (match retour): 01.09.2022 20:00 | vainqueur: Fluminense - RJ | ||||
| H (Match allé) | Sport Recife - PE | - | Cuiabá - MT | 1:1 (0:0) | ||
| R (match retour) | Cuiabá - MT | - | Sport Recife - PE | 2:0 (1:0) | ||
| H (Match allé): 25.08.2022 20:00 | R (match retour): 31.08.2022 22:00 | vainqueur: Cuiabá - MT | ||||
| H (Match allé) | Vila Nova - GO | - | Grêmio Porto Alegre | 1:0 (1:0) | ||
| R (match retour) | Grêmio Porto Alegre | - | Vila Nova - GO | 2:4 (2:2) | ||
| H (Match allé): 26.08.2022 20:00 | R (match retour): 31.08.2022 20:00 | vainqueur: Vila Nova - GO | ||||
