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| H (Match allé) | Internacional | - | Atlético Mineiro | 0:0 (0:0) | ||
| R (match retour) | Atlético Mineiro | - | Internacional | 0:1 (0:0) | ||
| H (Match allé): 31.10.2021 20:00 | R (match retour): 07.11.2021 15:00 | vainqueur: Internacional | ||||
| H (Match allé) | São Paulo FC | - | Flamengo RJ | 1:0 (1:0) | ||
| R (match retour) | Flamengo RJ | - | São Paulo FC | 1:1 (0:1) | ||
| H (Match allé): 01.11.2021 19:00 | R (match retour): 05.11.2021 19:30 | vainqueur: São Paulo FC | ||||
