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| H (Match allé) | Sport Recife - PE | - | Cruzeiro | 2:1 (1:1) | ||
| R (match retour) | Cruzeiro | - | Sport Recife - PE | 1:1 (1:1) | ||
| H (Match allé): 17.05.2022 20:30 | R (match retour): 23.05.2022 20:30 | vainqueur: Sport Recife - PE | ||||
| H (Match allé) | Vasco da Gama | - | Fluminense RJ | 2:1 (1:0) | ||
| R (match retour) | Fluminense RJ | - | Vasco da Gama | 4:5 (1:0, 2:1, 2:1) tab | ||
| H (Match allé): 18.05.2022 00:00 | R (match retour): 26.05.2022 02:30 | vainqueur: Vasco da Gama | ||||
| H (Match allé) | Atlético Mineiro | - | Palmeiras | 0:5 (0:2) | ||
| R (match retour) | Palmeiras | - | Atlético Mineiro | 3:1 (0:1) | ||
| H (Match allé): 18.05.2022 20:30 | R (match retour): 25.05.2022 00:00 | vainqueur: Palmeiras | ||||
| H (Match allé) | Bahia - BA | - | Fortaleza | 3:0 (2:0) | ||
| R (match retour) | Fortaleza | - | Bahia - BA | 1:2 (1:1) | ||
| H (Match allé): 19.05.2022 00:00 | R (match retour): 27.05.2022 00:00 | vainqueur: Bahia - BA | ||||
