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| H (Match allé) | Palmeiras | - | Athletico Paranaense | 3:2 (2:1) | ||
| R (match retour) | Athletico Paranaense | - | Palmeiras | 6:7 (2:3, 4:3, 4:3) tab | ||
| H (Match allé): 05.01.2021 20:00 | R (match retour): 09.01.2021 18:00 | vainqueur: Palmeiras | ||||
| H (Match allé) | Sport Recife - PE | - | Flamengo RJ | 1:2 (1:1) | ||
| R (match retour) | Flamengo RJ | - | Sport Recife - PE | 2:1 (1:1) | ||
| H (Match allé): 06.01.2021 19:00 | R (match retour): 10.01.2021 19:30 | vainqueur: Flamengo RJ | ||||
| H (Match allé) | São Paulo FC | - | River - PI | 4:0 (2:0) | ||
| R (match retour) | River - PI | - | São Paulo FC | 0:1 (0:1) | ||
| H (Match allé): 06.01.2021 20:00 | R (match retour): 10.01.2021 20:00 | vainqueur: São Paulo FC | ||||
| H (Match allé) | Atlético Mineiro | - | Fluminense RJ | 2:2 (1:0) | ||
| R (match retour) | Fluminense RJ | - | Atlético Mineiro | 4:1 (3:1) | ||
| H (Match allé): 06.01.2021 23:00 | R (match retour): 10.01.2021 22:15 | vainqueur: Fluminense RJ | ||||
