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| H (Match allé) | São Paulo FC | - | Flamengo RJ | 3:3 (2:3) | ||
| R (match retour) | Flamengo RJ | - | São Paulo FC | 2:1 (0:1) | ||
| H (Match allé): 24.07.2021 19:00 | R (match retour): 31.07.2021 19:00 | vainqueur: Flamengo RJ | ||||
| H (Match allé) | Cruzeiro | - | Vasco da Gama | 2:2 (0:1) | ||
| R (match retour) | Vasco da Gama | - | Cruzeiro | 6:2 (3:2) | ||
| H (Match allé): 25.07.2021 18:30 | R (match retour): 01.08.2021 15:30 | vainqueur: Vasco da Gama | ||||
