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| H (Match allé) | Figueirense - SC | - | Hercílio Luz - SC | 1:0 (1:0) | ||
| R (match retour) | Hercílio Luz - SC | - | Figueirense - SC | 0:0 (0:0) | ||
| H (Match allé): 12.03.2022 20:30 | R (match retour): 20.03.2022 15:00 | vainqueur: Figueirense - SC | ||||
| H (Match allé) | Marcílio Dias - SC | - | Camboriú - SC | 1:1 (1:1) | ||
| R (match retour) | Camboriú - SC | - | Marcílio Dias - SC | 3:2 (2:0) | ||
| H (Match allé): 12.03.2022 23:00 | R (match retour): 19.03.2022 23:00 | vainqueur: Camboriú - SC | ||||
| H (Match allé) | Chapecoense | - | Concórdia - SC | 1:1 (1:1) | ||
| R (match retour) | Concórdia - SC | - | Chapecoense | 1:1 (0:0) | ||
| H (Match allé): 13.03.2022 20:00 | R (match retour): 20.03.2022 20:00 | |||||
| H (Match allé) | Avaí - SC | - | Brusque - SC | 1:1 (1:1) | ||
| R (match retour) | Brusque - SC | - | Avaí - SC | 0:0 (0:0) | ||
| H (Match allé): 13.03.2022 22:30 | R (match retour): 19.03.2022 20:30 | vainqueur: Brusque - SC | ||||
