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| 27.10.2021 | 14:00 | Sloboda Tuzla | - | Zrinjski Mostar | 3:2 tab | |
| 14:30 | FK Omarska | - | Igman Konjic | 0:1 | ||
| 14:30 | Leotar Trebinje | - | Borac Banja Luka | 1:2 | ||
| 14:30 | HNK Sloga | - | Velež Mostar | 0:6 | ||
| 14:30 | Radnik Bijeljina | - | Široki Brijeg | 0:1 | ||
| 14:30 | Zvijezda Gradačac | - | HŠK Posušje | 6:5 tab | ||
| 16:30 | Željezničar Sarajevo | - | FK Tuzla City | 2:4 (1:3) | ||
| 17:30 | FK Sarajevo | - | Ljubić Prnjavor | 1:0 |
