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| H (Match allé) | Zvijezda Gradačac | - | Igman Konjic | 0:1 (0:0) | ||
| R (match retour) | Igman Konjic | - | Zvijezda Gradačac | 3:1 (2:0) | ||
| H (Match allé): 02.03.2022 13:00 | R (match retour): 16.03.2022 14:30 | vainqueur: Igman Konjic | ||||
| H (Match allé) | FK Tuzla City | - | Borac Banja Luka | 0:1 (0:1) | ||
| R (match retour) | Borac Banja Luka | - | FK Tuzla City | 3:4 (1:0, 1:2) tab | ||
| H (Match allé): 02.03.2022 15:00 | R (match retour): 16.03.2022 16:00 | vainqueur: FK Tuzla City | ||||
| H (Match allé) | FK Sarajevo | - | Sloboda Tuzla | 2:0 (1:0) | ||
| R (match retour) | Sloboda Tuzla | - | FK Sarajevo | 0:0 (0:0) | ||
| H (Match allé): 02.03.2022 17:00 | R (match retour): 16.03.2022 14:00 | vainqueur: FK Sarajevo | ||||
| H (Match allé) | Velež Mostar | - | Široki Brijeg | 4:0 (1:0) | ||
| R (match retour) | Široki Brijeg | - | Velež Mostar | 1:0 (0:0) | ||
| H (Match allé): 02.03.2022 19:00 | R (match retour): 16.03.2022 18:30 | vainqueur: Velež Mostar | ||||
