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| 25.10.2021 | 19:30 | KV Oostende II | - | KVC Westerlo II | 2:1 | |
| 19:30 | KAS Eupen II | - | Royal Excel Mouscron II | 2:1 | ||
| 20:00 | K Beerschot VA II | - | KV Kortrijk II | 4:2 | ||
| 20:00 | Lommel SK II | - | Lierse Kempenzonen II | 0:0 | ||
| 20:00 | Union St. Gilloise II | - | SK Beveren II | 0:1 | ||
| 20:30 | RWDM Brussels FC II | - | RFC Seraing II | 5:0 | ||
| 11.11.2021 | 15:00 | Excelsior Virton II | - | SK Deinze II | 5:2 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAS Eupen II | 8 | 6 | 1 | 1 | 20:9 | 11 | 19 |
| 2 |
|
KV Oostende II | 8 | 4 | 4 | 0 | 19:8 | 11 | 16 |
| 3 |
|
SK Beveren II | 8 | 5 | 1 | 2 | 15:6 | 9 | 16 |
| 4 |
|
K Beerschot VA II | 8 | 4 | 2 | 2 | 16:8 | 8 | 14 |
| 5 |
|
Lierse Kempenzonen II | 8 | 4 | 2 | 2 | 10:15 | -5 | 14 |
| 6 |
|
Royal Excel Mouscron II | 8 | 4 | 0 | 4 | 11:7 | 4 | 12 |
| 7 |
|
KVC Westerlo II | 8 | 4 | 0 | 4 | 10:10 | 0 | 12 |
| 8 |
|
Excelsior Virton II | 8 | 3 | 2 | 3 | 18:22 | -4 | 11 |
| 9 |
|
RWDM Brussels FC II | 8 | 3 | 1 | 4 | 19:19 | 0 | 10 |
| 10 |
|
Union St. Gilloise II | 8 | 3 | 1 | 4 | 6:8 | -2 | 10 |
| 11 |
|
SK Deinze II | 8 | 3 | 1 | 4 | 9:12 | -3 | 10 |
| 12 |
|
RFC Seraing II | 8 | 3 | 0 | 5 | 6:14 | -8 | 9 |
| 13 |
|
Lommel SK II | 8 | 1 | 2 | 5 | 9:16 | -7 | 5 |
| 14 |
|
KV Kortrijk II | 8 | 0 | 1 | 7 | 3:17 | -14 | 1 |
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