 |
 |
|
|
| 20.08.2021 | 20:45 | Standard Liège | - | KV Oostende | 1:0 (0:0) | |
| 21.08.2021 | 16:15 | RFC Seraing | - | Cercle Brugge | 2:1 (0:1) | |
| 18:30 | Oud-Heverlee Leuven | - | KAS Eupen | 1:4 (0:2) | ||
| 20:45 | Sint-Truidense VV | - | KV Kortrijk | 0:2 (0:1) | ||
| 22.08.2021 | 16:00 | SV Zulte Waregem | - | Sporting Charleroi | 2:2 (1:1) | |
| 18:30 | Club Brugge KV | - | K Beerschot VA | 3:2 (2:1) | ||
| 21:00 | KV Mechelen | - | Union Saint-Gilloise | 3:1 (1:1) | ||
| 22.09.2021 | 20:45 | Royal Antwerp FC | - | KRC Genk | 4:2 (3:1) | |
| 23.09.2021 | 20:45 | RSC Anderlecht | - | KAA Gent | 1:1 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAS Eupen | 5 | 3 | 2 | 0 | 12:6 | 6 | 11 |
| 2 |
|
Club Brugge KV | 5 | 3 | 2 | 0 | 11:5 | 6 | 11 |
| 3 |
|
Standard Liège | 5 | 3 | 1 | 1 | 7:7 | 0 | 10 |
| 4 |
|
Union Saint-Gilloise | 5 | 3 | 0 | 2 | 9:5 | 4 | 9 |
| 5 |
|
KV Kortrijk | 5 | 3 | 0 | 2 | 6:4 | 2 | 9 |
| 6 |
|
KV Oostende | 5 | 3 | 0 | 2 | 8:9 | -1 | 9 |
| 7 |
|
RSC Anderlecht | 5 | 2 | 2 | 1 | 8:6 | 2 | 8 |
| 8 |
|
Royal Antwerp FC | 5 | 2 | 1 | 2 | 12:9 | 3 | 7 |
| 9 |
|
Sporting Charleroi | 5 | 1 | 4 | 0 | 7:4 | 3 | 7 |
| 10 |
|
KRC Genk | 5 | 2 | 1 | 2 | 12:10 | 2 | 7 |
| 11 |
|
KV Mechelen | 5 | 2 | 0 | 3 | 7:9 | -2 | 6 |
| 12 |
|
RFC Seraing | 5 | 2 | 0 | 3 | 5:9 | -4 | 6 |
| 13 |
|
KAA Gent | 5 | 1 | 2 | 2 | 6:6 | 0 | 5 |
| 14 |
|
Cercle Brugge | 5 | 1 | 2 | 2 | 5:6 | -1 | 5 |
| 15 |
|
SV Zulte Waregem | 5 | 1 | 2 | 2 | 7:10 | -3 | 5 |
| 16 |
|
Sint-Truidense VV | 5 | 1 | 1 | 3 | 4:8 | -4 | 4 |
| 17 |
|
Oud-Heverlee Leuven | 5 | 0 | 3 | 2 | 4:11 | -7 | 3 |
| 18 |
|
K Beerschot VA | 5 | 0 | 1 | 4 | 4:10 | -6 | 1 |
| Play-off | |
| Play-off | |
| Relégation | |
| Relégation |
