 |
 |
|
|
| 22.10.2021 | 20:45 | RFC Seraing | - | Sporting Charleroi | 1:3 (0:2) | |
| 23.10.2021 | 16:15 | Cercle Brugge | - | Standard Liège | 1:1 (1:1) | |
| 18:30 | KV Kortrijk | - | KV Oostende | 1:0 (1:0) | ||
| 18:30 | KV Mechelen | - | SV Zulte Waregem | 2:2 (2:2) | ||
| 20:45 | KAS Eupen | - | Union Saint-Gilloise | 2:3 (0:2) | ||
| 24.10.2021 | 13:30 | Royal Antwerp FC | - | Club Brugge KV | 1:1 (1:1) | |
| 16:00 | RSC Anderlecht | - | K Beerschot VA | 4:2 (1:0) | ||
| 18:30 | KRC Genk | - | KAA Gent | 0:3 (0:1) | ||
| 21:00 | Oud-Heverlee Leuven | - | Sint-Truidense VV | 4:1 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Union Saint-Gilloise | 12 | 8 | 1 | 3 | 27:13 | 14 | 25 |
| 2 |
|
Club Brugge KV | 12 | 6 | 5 | 1 | 21:14 | 7 | 23 |
| 3 |
|
Royal Antwerp FC | 12 | 6 | 3 | 3 | 22:16 | 6 | 21 |
| 4 |
|
RSC Anderlecht | 12 | 5 | 5 | 2 | 25:16 | 9 | 20 |
| 5 |
|
Sporting Charleroi | 12 | 5 | 5 | 2 | 22:14 | 8 | 20 |
| 6 |
|
KAS Eupen | 12 | 6 | 2 | 4 | 23:17 | 6 | 20 |
| 7 |
|
KV Mechelen | 12 | 6 | 2 | 4 | 21:21 | 0 | 20 |
| 8 |
|
KV Kortrijk | 12 | 5 | 3 | 4 | 15:14 | 1 | 18 |
| 9 |
|
KAA Gent | 12 | 5 | 2 | 5 | 21:13 | 8 | 17 |
| 10 |
|
KRC Genk | 12 | 5 | 2 | 5 | 21:20 | 1 | 17 |
| 11 |
|
KV Oostende | 12 | 5 | 2 | 5 | 16:20 | -4 | 17 |
| 12 |
|
Sint-Truidense VV | 12 | 4 | 3 | 5 | 13:18 | -5 | 15 |
| 13 |
|
Standard Liège | 12 | 4 | 3 | 5 | 13:20 | -7 | 15 |
| 14 |
|
Oud-Heverlee Leuven | 12 | 2 | 7 | 3 | 15:20 | -5 | 13 |
| 15 |
|
SV Zulte Waregem | 12 | 3 | 4 | 5 | 19:26 | -7 | 13 |
| 16 |
|
RFC Seraing | 12 | 4 | 0 | 8 | 16:24 | -8 | 12 |
| 17 |
|
Cercle Brugge | 12 | 2 | 3 | 7 | 13:19 | -6 | 9 |
| 18 |
|
K Beerschot VA | 12 | 0 | 2 | 10 | 9:27 | -18 | 2 |
| Play-off | |
| Play-off | |
| Relégation | |
| Relégation |
