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| 24.08.2018 | 20:00 | KFC Dessel Sport | - | Oud-Heverlee Leuven | 3:1 (2:0) | |
| 25.08.2018 | 18:00 | SK Deinze | - | Racing White Brussels | 6:0 | |
| 20:00 | Lierse SK | - | Lommel SK | 2:3 | ||
| 20:00 | AFC Tubize | - | Stade Braine | 7:0 | ||
| 20:00 | Hoogstraten VV | - | RE Acren Lessines | 4:0 | ||
| 20:00 | Sportkring Sint-Niklaas | - | KRC Harelbeke | 0:1 ap | ||
| 20:00 | Union Saint-Gilloise | - | City Pirates Merksem | 3:0 | ||
| 26.08.2018 | 16:00 | Olympic Charleroi | - | KSV Roeselare | 2:1 | |
| 16:00 | KFC Duffel | - | KVC Westerlo | 3:0 | ||
| 16:00 | Olsa Brakel | - | Eendracht Aalst | 2:3 ap | ||
| 16:00 | KVK Westhoek | - | Excelsior Virton | 0:4 | ||
| 16:00 | KSK Heist | - | KSC Menen | 3:0 | ||
| 16:00 | RUS Givry | - | Royal Knokke FC | 3:5 tab | ||
| 18:00 | ASV Geel | - | KFCO Beerschot Wilrijk | 0:2 | ||
| 18:00 | KFC Mandel United | - | KSV Temse | 6:5 tab | ||
| 27.08.2018 | 20:30 | KV Mechelen | - | RUSG Quevy 89 | 2:0 |
