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| Recalificación | ||||||
|---|---|---|---|---|---|---|
| 24.11.2021 | 01:00 | TM Fútbol Club | - | Mineros de Zacatecas | 2:1 (1:0) | |
| 03:15 | Pumas Tabasco | - | Tepatitlán | 0:1 (0:1) | ||
| 05:15 | Cimarrones de Sonora | - | Venados FC | 1:2 (0:1) | ||
| 25.11.2021 | 00:00 | Leones Negros | - | Correcaminos UAT | 2:1 (1:1) | |
| Quarts de finale | ||||||
| 01.12.2021 | 02:00 | TM Fútbol Club | - | Atlético Morelia | 2:2 (0:1) | |
| 04:05 | Leones Negros | - | Club Celaya | 1:0 (0:0) | ||
| 02.12.2021 | 02:00 | Tepatitlán | - | Dorados de Sinaloa | 0:1 (0:0) | |
| 03.12.2021 | 02:00 | Venados FC | - | Atlante | 0:2 (0:1) | |
| 05.12.2021 | 00:00 | Atlético Morelia | - | TM Fútbol Club | 0:2 (0:1) | |
| 02:05 | Dorados de Sinaloa | - | Tepatitlán | 1:0 (0:0) | ||
| 19:00 | Atlante | - | Venados FC | 0:0 (0:0) | ||
| 06.12.2021 | 00:00 | Club Celaya | - | Leones Negros | 3:0 (2:0) | |
| Demi-finales | ||||||
| 09.12.2021 | 01:30 | TM Fútbol Club | - | Dorados de Sinaloa | 1:0 (1:0) | |
| 10.12.2021 | 01:30 | Club Celaya | - | Atlante | 0:1 (0:1) | |
| 12.12.2021 | 04:00 | Dorados de Sinaloa | - | TM Fútbol Club | 0:1 (0:1) | |
| 19:00 | Atlante | - | Club Celaya | 2:2 (0:0) | ||
| Finale | ||||||
| 16.12.2021 | 04:00 | TM Fútbol Club | - | Atlante | 0:0 (0:0) | |
| 19.12.2021 | 04:10 | Atlante | - | TM Fútbol Club | 3:0 (0:0) | |
