| 1. Journée | 17.07.2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
| 2. Journée | 22.07.2022 | Guaraní | - | General Caballero DJLM | 2:1 | ||||
| 3. Journée | 24.07.2022 | General Caballero DJLM | - | Libertad | 3:2 | ||||
| 6. Journée | 15.08.2022 | Sportivo Ameliano | - | General Caballero DJLM | 2:0 | ||||
| 8. Journée | 27.08.2022 | General Caballero DJLM | - | Cerro Porteño | 1:1 | ||||
| 9. Journée | 03.09.2022 | Resistencia SC | - | General Caballero DJLM | 0:0 | ||||
| 11. Journée | 17.09.2022 | Sol de América | - | General Caballero DJLM | 3:2 | ||||
| 12. Journée | 19.09.2022 | Club Nacional | - | General Caballero DJLM | 1:0 | ||||
| 15. Journée | 05.10.2022 | General Caballero DJLM | - | Guaireña FC | 0:0 | ||||
| 19. Journée | 28.10.2022 | Cerro Porteño | - | General Caballero DJLM | 2:1 |
Venezuela