| 1. Journée | 23.11.2021 | Hyderabad FC | - | Chennaiyin FC | 0:1 |  |
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| 3. Journée | 29.11.2021 | NorthEast United FC | - | Chennaiyin FC | 1:2 | ||||
| 4. Journée | 03.12.2021 | Chennaiyin FC | - | SC East Bengal | 0:0 | ||||
| 5. Journée | 11.12.2021 | ATK Mohun Bagan FC | - | Chennaiyin FC | 1:1 | |
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| 6. Journée | 15.12.2021 | Mumbai City FC | - | Chennaiyin FC | 1:0 | ||||
| 7. Journée | 18.12.2021 | Chennaiyin FC | - | Odisha FC | 2:1 | ||||
| 8. Journée | 22.12.2021 | Chennaiyin FC | - | Kerala Blasters | 0:3 | ||||
| 9. Journée | 30.12.2021 | Chennaiyin FC | - | Bengaluru FC | 2:4 | ||||
| 10. Journée | 02.01.2022 | Jamshedpur FC | - | Chennaiyin FC | 0:1 | ||||
| 11. Journée | 08.01.2022 | FC Goa | - | Chennaiyin FC | 1:0 | ||||
| 14. Journée | 22.01.2022 | Chennaiyin FC | - | NorthEast United FC | 2:1 | |
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| 15. Journée | 26.01.2022 | Bengaluru FC | - | Chennaiyin FC | 3:0 | ||||
| 16. Journée | 02.02.2022 | SC East Bengal | - | Chennaiyin FC | 2:2 | ||||
| 21. Journée | 16.02.2022 | Odisha FC | - | Chennaiyin FC | 2:2 | ||||
| 22. Journée | 20.02.2022 | Chennaiyin FC | - | Jamshedpur FC | 1:4 | ||||
| 19. Journée | 26.02.2022 | Kerala Blasters | - | Chennaiyin FC | 3:0 | |
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| 20. Journée | 03.03.2022 | Chennaiyin FC | - | ATK Mohun Bagan FC | 0:1 |
Ukraine