| 1. Journée | 08.08.2021 | Vida | - | Lobos UPNFM | 1:1 | ||||
| 2. Journée | 11.08.2021 | Marathón | - | Lobos UPNFM | 5:1 |  |
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| 3. Journée | 15.08.2021 | Lobos UPNFM | - | Honduras Progreso | 3:0 | ||||
| 4. Journée | 22.08.2021 | Lobos UPNFM | - | Platense | 3:0 | ||||
| 5. Journée | 26.08.2021 | Real España | - | Lobos UPNFM | 5:3 | ||||
| 6. Journée | 31.08.2021 | Motagua | - | Lobos UPNFM | 0:0 |  |
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| 8. Journée | 12.09.2021 | Lobos UPNFM | - | Olimpia | 0:0 | ||||
| 16. Journée | 27.10.2021 | Real Sociedad | - | Lobos UPNFM | 0:3 |
Honduras