| 1. Journée | 13.03.2022 | Sacramento Republic | - | El Paso Locomotive | 3:1 | ||||
| 1. Journée | 20.03.2022 | El Paso Locomotive | - | New Mexico United | 1:2 | ||||
| 2. Journée | 03.04.2022 | San Diego Loyal | - | El Paso Locomotive | 3:2 | ||||
| 2. Journée | 10.04.2022 | El Paso Locomotive | - | Monterey Bay FC | 5:0 | ||||
| 2. Journée | 17.04.2022 | San Antonio FC | - | El Paso Locomotive | 1:0 | ||||
| 3. Journée | 08.05.2022 | El Paso Locomotive | - | Los Angeles Galaxy II | 4:0 | ||||
| 3. Journée | 15.05.2022 | Pittsburgh Riverhounds | - | El Paso Locomotive | 1:0 | ||||
| 3. Journée | 19.05.2022 | El Paso Locomotive | - | Sacramento Republic | 1:0 | ||||
| 3. Journée | 22.05.2022 | Orange County SC | - | El Paso Locomotive | 2:2 | ||||
| 3. Journée | 28.05.2022 | Las Vegas Lights FC | - | El Paso Locomotive | 0:1 | ||||
| 4. Journée | 26.06.2022 | El Paso Locomotive | - | New York RB II | 5:0 |  |
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| 4. Journée | 30.06.2022 | Rio Grande Valley FC | - | El Paso Locomotive | 0:0 |
Canada