| 1. Journée | 25.08.2010 | River Plate | - | Defensor Sporting | 1:1 | ||||
| 3. Journée | 05.09.2010 | River Plate | - | Central Español | 1:3 | ||||
| 11. Journée | 07.11.2010 | Miramar Misiones | - | River Plate | 1:1 | ||||
| 12. Journée | 14.11.2010 | River Plate | - | El Tanque Sisley | 1:2 |  |
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| 13. Journée | 21.11.2010 | Montevideo Wanderers | - | River Plate | 1:2 | ||||
| 14. Journée | 27.11.2010 | River Plate | - | Fénix | 1:2 | |
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| 15. Journée | 05.12.2010 | Bella Vista | - | River Plate | 1:0 |
Uruguay