| 1. Journée | 11.09.2021 | Cerro Largo | - | Nacional | 0:3 | ||||
| 2. Journée | 18.09.2021 | Cerrito | - | Cerro Largo | 1:1 | ||||
| 3. Journée | 25.09.2021 | Cerro Largo | - | Liverpool | 3:0 |  |
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| 4. Journée | 02.10.2021 | River Plate | - | Cerro Largo | 0:4 | ||||
| 5. Journée | 09.10.2021 | Cerro Largo | - | Deportivo Maldonado | 1:1 | ||||
| 6. Journée | 17.10.2021 | Cerro Largo | - | Progreso | 1:0 | ||||
| 7. Journée | 21.10.2021 | Sud América | - | Cerro Largo | 0:0 | |
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| 9. Journée | 31.10.2021 | Fénix | - | Cerro Largo | 1:4 | ||||
| 10. Journée | 04.11.2021 | Cerro Largo | - | Boston River | 1:1 | ||||
| 11. Journée | 08.11.2021 | Montevideo Wanderers | - | Cerro Largo | 1:2 | |
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| 14. Journée | 29.11.2021 | Cerro Largo | - | Montevideo City Torque | 1:1 | |
Uruguay