| 12. Journée | 04.04.2022 | ART Municipal Jalapa | - | UNAN Managua | 1:1 | ||||
| 13. Journée | 08.04.2022 | CD Walter Ferretti | - | ART Municipal Jalapa | 4:1 | ||||
| 15. Journée | 14.04.2022 | ART Municipal Jalapa | - | H&H Export Sébaco | 1:0 | ||||
| 16. Journée | 25.04.2022 | Real Madriz | - | ART Municipal Jalapa | 3:0 |  |
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| 17. Journée | 29.04.2022 | Juventus Managua | - | ART Municipal Jalapa | 2:1 |
Nicaragua