| 1. Journée | 29.08.2021 | Beitar Jerusalem | - | Hapoel Be'er Sheva | 0:2 | ||||
| 2. Journée | 12.09.2021 | Hapoel Be'er Sheva | - | Hapoel Hadera | 2:2 | ||||
| 3. Journée | 18.09.2021 | Bnei Sachnin FC | - | Hapoel Be'er Sheva | 0:0 |  |
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| 4. Journée | 25.09.2021 | Hapoel Be'er Sheva | - | Maccabi Tel Aviv | 2:0 | ||||
| 5. Journée | 03.10.2021 | Maccabi Haifa | - | Hapoel Be'er Sheva | 1:2 |  |
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| 7. Journée | 23.10.2021 | Hapoel Be'er Sheva | - | Hapoel Jerusalem | 3:1 | ||||
| 8. Journée | 30.10.2021 | Maccabi Netanya | - | Hapoel Be'er Sheva | 1:1 | ||||
| 9. Journée | 06.11.2021 | Hapoel Be'er Sheva | - | FC Ashdod | 1:1 | ||||
| 11. Journée | 01.12.2021 | Hapoel Be'er Sheva | - | Hapoel Tel Aviv | 2:1 | ||||
| 13. Journée | 12.12.2021 | Hapoel Be'er Sheva | - | Hapoel Nof HaGalil | 2:0 | ||||
| 14. Journée | 22.12.2021 | Hapoel Be'er Sheva | - | Beitar Jerusalem | 3:1 | ||||
| 16. Journée | 02.01.2022 | Hapoel Be'er Sheva | - | Bnei Sachnin FC | 3:0 | ||||
| 24. Journée | 26.02.2022 | Hapoel Tel Aviv | - | Hapoel Be'er Sheva | 1:1 | ||||
| 25. Journée | 06.03.2022 | Hapoel Be'er Sheva | - | Hapoel Haifa | 3:1 | |
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| 26. Journée | 13.03.2022 | Hapoel Nof HaGalil | - | Hapoel Be'er Sheva | 0:2 |
Israël