| 2. Journée | 29.01.2019 | River Plate | - | Sportivo Luqueño | 2:1 | ||||
| 3. Journée | 02.02.2019 | Deportivo Santaní | - | River Plate | 1:1 |  |
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| 4. Journée | 05.02.2019 | River Plate | - | Sol de América | 1:0 | |
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| 5. Journée | 11.02.2019 | Cerro Porteño | - | River Plate | 3:1 | ||||
| 6. Journée | 17.02.2019 | River Plate | - | Libertad | 1:1 | ||||
| 12. Journée | 24.03.2019 | River Plate | - | San Lorenzo | 2:1 | ||||
| 14. Journée | 04.04.2019 | River Plate | - | Deportivo Santaní | 1:2 | ||||
| 15. Journée | 09.04.2019 | Sol de América | - | River Plate | 0:1 | ||||
| 16. Journée | 14.04.2019 | River Plate | - | Cerro Porteño | 1:5 | |
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| 17. Journée | 21.04.2019 | Libertad | - | River Plate | 2:1 | |
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| 18. Journée | 28.04.2019 | River Plate | - | Deportivo Capiatá | 1:0 | ||||
| 19. Journée | 01.05.2019 | General Díaz | - | River Plate | 0:1 | |
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| 21. Journée | 14.05.2019 | River Plate | - | Club Olimpia | 2:2 | ||||
| 22. Journée | 19.05.2019 | Club Nacional | - | River Plate | 0:0 |
Uruguay