| 1. Journée | 08.01.2022 | Club Tijuana [] | - | Club León [] | 3:2 | ||||
| 5. Journée | 05.02.2022 | Club Tijuana [] | - | Deportivo Guadalajara [] | 1:2 | ||||
| 6. Journée | 12.02.2022 | Mazatlán FC [] | - | Club Tijuana [] | 1:3 | ||||
| 9. Journée | 05.03.2022 | Santos Laguna [] | - | Club Tijuana [] | 2:1 | ||||
| 11. Journée | 19.03.2022 | Deportivo Guadalajara [] | - | Club Tijuana [] | 3:0 | ||||
| 17. Journée | 30.04.2022 | Club Tijuana [] | - | Mazatlán FC [] | 4:0 |
Mexique