| 1. Journée | 03.09.2022 | Twente/Heracles [U21] | - | NAC Breda [U21] | 6:2 |  |
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| 2. Journée | 10.09.2022 | FC Den Bosch [U21] | - | Twente/Heracles [U21] | 1:0 | ||||
| 3. Journée | 16.09.2022 | Twente/Heracles [U21] | - | Vitesse [U21] | 2:0 | |
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| 4. Journée | 01.10.2022 | Roda JC Kerkrade [U21] | - | Twente/Heracles [U21] | 0:3 | |
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| 5. Journée | 08.10.2022 | Twente/Heracles [U21] | - | Go Ahead Eagles [U21] | 2:0 | |
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| 6. Journée | 15.10.2022 | NEC Nijmegen [U21] | - | Twente/Heracles [U21] | 0:0 | ||||
| 7. Journée | 22.10.2022 | Twente/Heracles [U21] | - | VVV-Venlo [U21] | 2:1 | |
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| 8. Journée | 29.10.2022 | NAC Breda [U21] | - | Twente/Heracles [U21] | 0:1 | ||||
| 9. Journée | 05.11.2022 | Twente/Heracles [U21] | - | FC Den Bosch [U21] | 1:0 | |
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| 10. Journée | 11.11.2022 | Vitesse [U21] | - | Twente/Heracles [U21] | 2:4 | ||||
| 11. Journée | 19.11.2022 | Twente/Heracles [U21] | - | Roda JC Kerkrade [U21] | 5:1 | |
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| 12. Journée | 25.11.2022 | Go Ahead Eagles [U21] | - | Twente/Heracles [U21] | 0:3 | |
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| 13. Journée | 06.12.2022 | Twente/Heracles [U21] | - | NEC Nijmegen [U21] | 2:0 | |
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| 14. Journée | 17.12.2022 | VVV-Venlo [U21] | - | Twente/Heracles [U21] | 1:1 |
Pays-Bas