| 4. Journée | 18.09.2021 | Kaizer Chiefs | - | Royal AM | 1:4 | ||||
| 6. Journée | 02.10.2021 | AmaZulu FC | - | Kaizer Chiefs | 1:1 | ||||
| 7. Journée | 16.10.2021 | Kaizer Chiefs | - | Chippa United | 4:0 | ||||
| 8. Journée | 24.10.2021 | SuperSport United | - | Kaizer Chiefs | 1:2 | ||||
| 9. Journée | 02.11.2021 | Kaizer Chiefs | - | Stellenbosch FC | 0:1 | ||||
| 10. Journée | 06.11.2021 | Kaizer Chiefs | - | Orlando Pirates | 2:1 | ||||
| 11. Journée | 21.11.2021 | Maritzburg United | - | Kaizer Chiefs | 0:1 |  |
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| 19. Journée | 24.11.2021 | Kaizer Chiefs | - | AmaZulu FC | 1:1 | ||||
| 15. Journée | 12.12.2021 | Kaizer Chiefs | - | Sekhukhune United | 2:0 | ||||
| 17. Journée | 22.12.2021 | Kaizer Chiefs | - | Maritzburg United | 2:0 | ||||
| 21. Journée | 05.03.2022 | Orlando Pirates | - | Kaizer Chiefs | 1:2 | ||||
| 22. Journée | 19.03.2022 | Kaizer Chiefs | - | Golden Arrows | 0:1 | ||||
| 24. Journée | 05.04.2022 | Kaizer Chiefs | - | TS Galaxy | 0:0 | ||||
| 26. Journée | 23.04.2022 | Stellenbosch FC | - | Kaizer Chiefs | 1:0 | ||||
| 14. Journée | 27.04.2022 | Golden Arrows | - | Kaizer Chiefs | 2:1 | ||||
| 30. Journée | 21.05.2022 | Kaizer Chiefs | - | Moroka Swallows | 2:2 |  |
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Afrique du Sud