| 1. Journée | 05.02.2011 | Defensor Sporting | - | River Plate | 4:1 | ||||
| 2. Journée | 13.02.2011 | River Plate | - | Rampla Juniors | 1:2 | ||||
| 3. Journée | 19.02.2011 | Central Español | - | River Plate | 2:0 |  |
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| 4. Journée | 27.02.2011 | River Plate | - | Racing | 1:4 | ||||
| 5. Journée | 07.03.2011 | Tacuarembó | - | River Plate | 2:1 | ||||
| 6. Journée | 13.03.2011 | River Plate | - | Danubio | 3:1 | |
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| 8. Journée | 02.04.2011 | River Plate | - | CA Cerro | 3:4 | ||||
| 9. Journée | 10.04.2011 | Liverpool | - | River Plate | 1:1 | |
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| 10. Journée | 16.04.2011 | River Plate | - | Nacional | 4:2 | ||||
| 11. Journée | 24.04.2011 | River Plate | - | Miramar Misiones | 2:1 | ||||
| 12. Journée | 07.05.2011 | El Tanque Sisley | - | River Plate | 2:1 | |
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| 7. Journée | 15.05.2011 | Peñarol | - | River Plate | 1:4 | |
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| 14. Journée | 29.05.2011 | Fénix | - | River Plate | 4:1 | ||||
| 15. Journée | 05.06.2011 | River Plate | - | Bella Vista | 2:2 | |
Uruguay