| 1. Journée | 18.04.2021 | Columbus Crew | - | Philadelphia Union | 0:0 | ||||
| 3. Journée | 24.06.2021 | Philadelphia Union | - | Columbus Crew | 1:0 | ||||
| 3. Journée | 28.06.2021 | Austin FC | - | Columbus Crew | 0:0 | ||||
| 4. Journée | 03.07.2021 | Columbus Crew | - | New England Revolution | 2:2 | ||||
| 6. Journée | 12.09.2021 | Inter Miami CF | - | Columbus Crew | 1:0 | ||||
| 6. Journée | 19.09.2021 | New England Revolution | - | Columbus Crew | 1:1 | ||||
| 6. Journée | 26.09.2021 | Columbus Crew | - | CF Montréal | 2:1 | ||||
| 7. Journée | 03.10.2021 | Philadelphia Union | - | Columbus Crew | 3:0 | ||||
| 7. Journée | 17.10.2021 | Columbus Crew | - | Inter Miami CF | 4:0 | ||||
| 7. Journée | 21.10.2021 | Nashville SC | - | Columbus Crew | 1:1 | ||||
| 7. Journée | 24.10.2021 | Columbus Crew | - | New York RB | 1:2 | ||||
| 7. Journée | 28.10.2021 | Columbus Crew | - | Orlando City | 3:2 |  |
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| 7. Journée | 31.10.2021 | D.C. United | - | Columbus Crew | 1:3 | |
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| 8. Journée | 07.11.2021 | Columbus Crew | - | Chicago Fire | 2:0 |
Argentine
États-Unis