| 1. Journée | 25.08.2010 | River Plate | - | Defensor Sporting | 1:1 | ||||
| 2. Journée | 29.08.2010 | Rampla Juniors | - | River Plate | 0:1 |  |
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| 3. Journée | 05.09.2010 | River Plate | - | Central Español | 1:3 | ||||
| 4. Journée | 18.09.2010 | Racing | - | River Plate | 2:0 | |
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| 5. Journée | 25.09.2010 | River Plate | - | Tacuarembó | 2:0 | |
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| 6. Journée | 03.10.2010 | Danubio | - | River Plate | 1:2 | |
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| 7. Journée | 09.10.2010 | River Plate | - | Peñarol | 2:1 | ||||
| 8. Journée | 16.10.2010 | CA Cerro | - | River Plate | 0:0 | ||||
| 9. Journée | 24.10.2010 | River Plate | - | Liverpool | 1:2 | ||||
| 10. Journée | 30.10.2010 | Nacional | - | River Plate | 6:1 | ||||
| 11. Journée | 07.11.2010 | Miramar Misiones | - | River Plate | 1:1 | ||||
| 12. Journée | 14.11.2010 | River Plate | - | El Tanque Sisley | 1:2 | ||||
| 13. Journée | 21.11.2010 | Montevideo Wanderers | - | River Plate | 1:2 | ||||
| 14. Journée | 27.11.2010 | River Plate | - | Fénix | 1:2 | ||||
| 15. Journée | 05.12.2010 | Bella Vista | - | River Plate | 1:0 | |
Uruguay