| 1. Journée | 07.02.2022 | River Plate | - | Montevideo Wanderers | 1:1 |  |
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| 2. Journée | 12.02.2022 | Plaza Colonia | - | River Plate | 0:1 | ||||
| 3. Journée | 19.02.2022 | River Plate | - | Boston River | 1:2 | ||||
| 4. Journée | 28.02.2022 | River Plate | - | Cerrito | 3:1 |  |
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| 5. Journée | 05.03.2022 | River Plate | - | Cerro Largo | 1:1 | ||||
| 7. Journée | 03.04.2022 | Defensor Sporting | - | River Plate | 3:2 | ||||
| 8. Journée | 10.04.2022 | River Plate | - | Albion | 4:1 | |
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| 10. Journée | 23.04.2022 | River Plate | - | Danubio | 0:0 | ||||
| 11. Journée | 07.05.2022 | Deportivo Maldonado | - | River Plate | 2:1 | |
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| 12. Journée | 13.05.2022 | River Plate | - | Rentistas | 1:0 | ||||
| 13. Journée | 22.05.2022 | Liverpool | - | River Plate | 2:1 | ||||
| 14. Journée | 29.05.2022 | River Plate | - | Peñarol | 0:0 | ||||
| 15. Journée | 04.06.2022 | Montevideo City Torque | - | River Plate | 0:0 |
Uruguay