| 1. Journée | 31.07.2022 | Montevideo Wanderers | - | River Plate | 1:2 | ||||
| 2. Journée | 06.08.2022 | River Plate | - | Plaza Colonia | 2:0 | ||||
| 3. Journée | 12.08.2022 | Boston River | - | River Plate | 1:2 | ||||
| 6. Journée | 20.08.2022 | Fénix | - | River Plate | 1:2 |  |
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| 5. Journée | 29.08.2022 | Cerro Largo | - | River Plate | 0:5 | |
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| 4. Journée | 05.09.2022 | Cerrito | - | River Plate | 1:5 | ||||
| 7. Journée | 11.09.2022 | River Plate | - | Defensor Sporting | 0:1 | |
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| 8. Journée | 14.09.2022 | Albion | - | River Plate | 0:2 |  |
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| 9. Journée | 17.09.2022 | River Plate | - | Nacional | 1:1 | ||||
| 10. Journée | 24.09.2022 | Danubio | - | River Plate | 3:0 | ||||
| 11. Journée | 02.10.2022 | River Plate | - | Deportivo Maldonado | 0:0 | |
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| 12. Journée | 08.10.2022 | Rentistas | - | River Plate | 0:5 | ||||
| 13. Journée | 13.10.2022 | River Plate | - | Liverpool | 0:1 | |
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| 15. Journée | 21.10.2022 | River Plate | - | Montevideo City Torque | 2:1 | |
Uruguay