| 6. Journée | 21.08.2022 | Defensor Sporting | - | Boston River | 0:1 |  |
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| 5. Journée | 27.08.2022 | Boston River | - | Fénix | 1:1 | ||||
| 4. Journée | 04.09.2022 | Cerro Largo | - | Boston River | 1:1 |  |
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| 7. Journée | 10.09.2022 | Boston River | - | Albion | 1:0 | |
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| 8. Journée | 15.09.2022 | Nacional | - | Boston River | 1:0 |  |
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| 10. Journée | 24.09.2022 | Deportivo Maldonado | - | Boston River | 2:1 | ||||
| 11. Journée | 02.10.2022 | Boston River | - | Rentistas | 3:0 | ||||
| 12. Journée | 09.10.2022 | Liverpool | - | Boston River | 3:2 | |
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| 13. Journée | 13.10.2022 | Boston River | - | Peñarol | 2:1 | ||||
| 14. Journée | 17.10.2022 | Montevideo City Torque | - | Boston River | 0:2 | ||||
| 15. Journée | 24.10.2022 | Boston River | - | Montevideo Wanderers | 2:2 | |
Uruguay