| 1. Journée | 13.08.2021 | NK Sesvete | - | NK Osijek II | 1:4 |  |
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| 2. Journée | 20.08.2021 | NK Osijek II | - | Dinamo Zagreb II | 1:1 | |
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| 3. Journée | 28.08.2021 | NK Dugopolje | - | NK Osijek II | 0:0 | ||||
| 4. Journée | 10.09.2021 | NK Osijek II | - | NK Solin | 3:2 | ||||
| 5. Journée | 15.09.2021 | NK Dubrava | - | NK Osijek II | 3:0 | ||||
| 6. Journée | 19.09.2021 | NK Osijek II | - | NK Croatia Zmijavci | 1:2 | ||||
| 7. Journée | 26.09.2021 | HNK Orijent Rijeka | - | NK Osijek II | 0:1 | ||||
| 8. Journée | 02.10.2021 | NK Osijek II | - | NK Opatija | 0:2 | ||||
| 9. Journée | 16.10.2021 | HNK Cibalia | - | NK Osijek II | 1:0 | ||||
| 10. Journée | 24.10.2021 | NK Osijek II | - | NK Varaždin | 0:0 |  |
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| 12. Journée | 07.11.2021 | NK Osijek II | - | NK Rudeš | 2:1 | ||||
| 11. Journée | 12.11.2021 | NK Inter Zaprešić | - | NK Osijek II | 2:0 | |
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| 13. Journée | 19.11.2021 | NK Kustošija | - | NK Osijek II | 0:0 | |
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| 15. Journée | 05.12.2021 | NK BSK Bijelo Brdo | - | NK Osijek II | 0:2 |
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