| 1. Journée | 01.08.2022 | Liverpool | - | Defensor Sporting | 1:3 |  |
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| 2. Journée | 07.08.2022 | Defensor Sporting | - | Peñarol | 2:3 | ||||
| 3. Journée | 14.08.2022 | Montevideo City Torque | - | Defensor Sporting | 0:2 | |
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| 5. Journée | 28.08.2022 | Plaza Colonia | - | Defensor Sporting | 0:1 | |
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| 4. Journée | 03.09.2022 | Defensor Sporting | - | Montevideo Wanderers | 1:0 | ||||
| 7. Journée | 11.09.2022 | River Plate | - | Defensor Sporting | 0:1 | ||||
| 8. Journée | 16.09.2022 | Defensor Sporting | - | Cerro Largo | 0:1 | ||||
| 9. Journée | 20.09.2022 | Fénix | - | Defensor Sporting | 0:0 | ||||
| 11. Journée | 02.10.2022 | Defensor Sporting | - | Albion | 2:0 | |
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| 12. Journée | 09.10.2022 | Nacional | - | Defensor Sporting | 1:1 | ||||
| 13. Journée | 13.10.2022 | Defensor Sporting | - | Danubio | 1:1 | |
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| 14. Journée | 15.10.2022 | Deportivo Maldonado | - | Defensor Sporting | 0:0 |  |
Uruguay