| 1. Journée | 20.08.2021 | Mamelodi Sundowns | - | AmaZulu FC | 1:0 | ||||
| 2. Journée | 24.08.2021 | Chippa United | - | Mamelodi Sundowns | 0:0 |  |
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| 3. Journée | 12.09.2021 | Mamelodi Sundowns | - | Kaizer Chiefs | 2:0 | ||||
| 4. Journée | 19.09.2021 | Mamelodi Sundowns | - | TS Galaxy | 3:0 | ||||
| 7. Journée | 20.10.2021 | Golden Arrows | - | Mamelodi Sundowns | 0:1 |  |
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| 19. Journée | 24.11.2021 | Mamelodi Sundowns | - | SuperSport United | 2:2 | ||||
| 14. Journée | 08.12.2021 | Mamelodi Sundowns | - | Royal AM | 3:2 | |
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| 15. Journée | 11.12.2021 | SuperSport United | - | Mamelodi Sundowns | 0:1 | ||||
| 18. Journée | 07.02.2022 | Mamelodi Sundowns | - | Chippa United | 2:0 | ||||
| 25. Journée | 12.04.2022 | Mamelodi Sundowns | - | Golden Arrows | 6:0 | |
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| 26. Journée | 27.04.2022 | Mamelodi Sundowns | - | Cape Town City FC | 0:0 | ||||
| 27. Journée | 03.05.2022 | Sekhukhune United | - | Mamelodi Sundowns | 0:2 | ||||
| 28. Journée | 08.05.2022 | Kaizer Chiefs | - | Mamelodi Sundowns | 1:1 | ||||
| 29. Journée | 14.05.2022 | Mamelodi Sundowns | - | Stellenbosch FC | 0:3 | ||||
| 30. Journée | 23.05.2022 | Royal AM | - | Mamelodi Sundowns | 2:3 | |
Uruguay