| 1. Journée | 20.01.2022 | Honduras Progreso | - | Motagua | 2:1 | ||||
| 2. Journée | 23.01.2022 | Honduras Progreso | - | Lobos UPNFM | 1:2 | ||||
| 3. Journée | 06.02.2022 | Olimpia | - | Honduras Progreso | 3:0 | ||||
| 4. Journée | 10.02.2022 | Real Sociedad | - | Honduras Progreso | 4:2 | ||||
| 7. Journée | 27.02.2022 | Real España | - | Honduras Progreso | 3:0 |  |
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| 8. Journée | 04.03.2022 | Honduras Progreso | - | Victoria | 2:1 | ||||
| 9. Journée | 07.03.2022 | Platense | - | Honduras Progreso | 0:0 | ||||
| 13. Journée | 07.04.2022 | Marathón | - | Honduras Progreso | 1:1 | ||||
| 14. Journée | 10.04.2022 | Honduras Progreso | - | Vida | 3:1 | ||||
| 15. Journée | 14.04.2022 | Victoria | - | Honduras Progreso | 2:2 |  |
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| 16. Journée | 21.04.2022 | Motagua | - | Honduras Progreso | 3:2 | ||||
| 18. Journée | 01.05.2022 | Honduras Progreso | - | Platense | 3:1 |
Honduras