| 1. Journée | 17.07.2021 | Newell's Old Boys | - | Talleres de Córdoba | 3:2 |  |
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| 9. Journée | 30.08.2021 | Newell's Old Boys | - | Atlético Tucumán | 1:2 | ||||
| 10. Journée | 04.09.2021 | Colón de Santa Fe | - | Newell's Old Boys | 1:1 | ||||
| 11. Journée | 16.09.2021 | Newell's Old Boys | - | River Plate | 1:4 | |
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| 12. Journée | 20.09.2021 | Lanús | - | Newell's Old Boys | 1:2 | |
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| 20. Journée | 08.11.2021 | Newell's Old Boys | - | Unión de Santa Fe | 1:0 | ||||
| 22. Journée | 24.11.2021 | Newell's Old Boys | - | Central Córdoba SdE | 1:0 | ||||
| 23. Journée | 30.11.2021 | Boca Juniors | - | Newell's Old Boys | 0:0 | ||||
| 24. Journée | 07.12.2021 | Newell's Old Boys | - | Banfield | 0:0 | ||||
| 25. Journée | 12.12.2021 | San Lorenzo | - | Newell's Old Boys | 3:2 |  |
Argentine