| 2. Journée | 13.03.2021 | CD Guabirá | - | Bolívar | 3:1 | ||||
| 1. Journée | 21.03.2021 | Blooming | - | CD Guabirá | 0:1 | ||||
| 3. Journée | 02.04.2021 | Club Aurora | - | CD Guabirá | 2:1 | ||||
| 4. Journée | 11.04.2021 | CD Guabirá | - | Real Tomayapo | 0:2 | ||||
| 5. Journée | 24.04.2021 | Club San José | - | CD Guabirá | 0:1 | ||||
| 7. Journée | 09.05.2021 | Nacional Potosí | - | CD Guabirá | 2:1 | ||||
| 8. Journée | 11.07.2021 | CD Guabirá | - | Oriente Petrolero | 1:1 | ||||
| 9. Journée | 18.07.2021 | The Strongest | - | CD Guabirá | 2:1 | ||||
| 10. Journée | 22.07.2021 | CD Guabirá | - | Jorge Wilstermann | 3:2 | ||||
| 16. Journée | 18.08.2021 | CD Guabirá | - | Blooming | 4:2 | ||||
| 17. Journée | 22.08.2021 | Bolívar | - | CD Guabirá | 6:0 | ||||
| 20. Journée | 21.09.2021 | CD Guabirá | - | Club San José | 4:0 | ||||
| 21. Journée | 27.09.2021 | Real Santa Cruz | - | CD Guabirá | 3:0 | ||||
| 24. Journée | 26.10.2021 | CD Guabirá | - | The Strongest | 0:0 | ||||
| 25. Journée | 30.10.2021 | Jorge Wilstermann | - | CD Guabirá | 2:1 | ||||
| 26. Journée | 20.11.2021 | CD Guabirá | - | Atlético Palmaflor | 2:0 |  |
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| 27. Journée | 27.11.2021 | Always Ready | - | CD Guabirá | 6:1 |
Bolivie