| 1. Journée | 06.02.2022 | Club Aurora | - | CD Guabirá | 0:0 | ||||
| 2. Journée | 13.02.2022 | Real Santa Cruz | - | CD Guabirá | 2:2 | ||||
| 3. Journée | 21.02.2022 | Oriente Petrolero | - | CD Guabirá | 2:1 | ||||
| 4. Journée | 25.02.2022 | CD Guabirá | - | Nacional Potosí | 1:3 | ||||
| 5. Journée | 05.03.2022 | Atlético Palmaflor | - | CD Guabirá | 1:0 | ||||
| 6. Journée | 21.03.2022 | CD Guabirá | - | Royal Pari | 0:3 | ||||
| 7. Journée | 03.04.2022 | CD Guabirá | - | The Strongest | 1:3 | ||||
| 8. Journée | 10.04.2022 | Universitario de Sucre | - | CD Guabirá | 2:0 | ||||
| 9. Journée | 17.04.2022 | CD Guabirá | - | Club Aurora | 3:2 |  |
|||
| 10. Journée | 22.04.2022 | CD Guabirá | - | Real Santa Cruz | 1:0 |  |
|||
| 11. Journée | 24.04.2022 | CD Guabirá | - | Oriente Petrolero | 0:0 | ||||
| 12. Journée | 29.04.2022 | CD Guabirá | - | Nacional Potosí | 1:2 | |
|||
| 13. Journée | 07.05.2022 | Royal Pari | - | CD Guabirá | 1:3 | ||||
| 14. Journée | 11.05.2022 | CD Guabirá | - | Atlético Palmaflor | 3:0 | ||||
| 15. Journée | 14.05.2022 | The Strongest | - | CD Guabirá | 0:0 | |
|||
| 16. Journée | 20.05.2022 | CD Guabirá | - | Universitario de Sucre | 1:0 |
Bolivie