| 1. Journée | 18.01.2021 | Plaza Colonia | - | Liverpool | 0:0 |  |
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| 2. Journée | 21.01.2021 | Plaza Colonia | - | Progreso | 0:1 | ||||
| 3. Journée | 29.01.2021 | Fénix | - | Plaza Colonia | 3:3 |  |
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| 5. Journée | 07.02.2021 | Defensor Sporting | - | Plaza Colonia | 3:2 | |
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| 6. Journée | 10.02.2021 | Plaza Colonia | - | Danubio | 3:0 | ||||
| 7. Journée | 14.02.2021 | Nacional | - | Plaza Colonia | 1:1 | |
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| 8. Journée | 19.02.2021 | Plaza Colonia | - | Boston River | 3:0 | ||||
| 9. Journée | 22.02.2021 | Deportivo Maldonado | - | Plaza Colonia | 1:1 | |
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| 10. Journée | 01.03.2021 | Plaza Colonia | - | Rentistas | 5:0 | ||||
| 11. Journée | 07.03.2021 | Cerro Largo | - | Plaza Colonia | 3:1 | ||||
| 12. Journée | 12.03.2021 | Plaza Colonia | - | Montevideo Wanderers | 3:0 | ||||
| 13. Journée | 20.03.2021 | Peñarol | - | Plaza Colonia | 1:3 | |
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| 14. Journée | 26.03.2021 | Plaza Colonia | - | River Plate | 1:0 | ||||
| 15. Journée | 29.03.2021 | Montevideo City Torque | - | Plaza Colonia | 2:0 | |
Uruguay