| 1. Journée | 27.02.2022 | Austin FC | - | FC Cincinnati | 5:0 |  |
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| 2. Journée | 06.03.2022 | Austin FC | - | Inter Miami CF | 5:1 | ||||
| 2. Journée | 13.03.2022 | Portland Timbers | - | Austin FC | 1:0 | |
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| 3. Journée | 03.04.2022 | San Jose Earthquakes | - | Austin FC | 2:2 | ||||
| 3. Journée | 11.04.2022 | Austin FC | - | Minnesota United FC | 1:0 | ||||
| 3. Journée | 17.04.2022 | D.C. United | - | Austin FC | 2:3 | ||||
| 3. Journée | 30.04.2022 | Houston Dynamo | - | Austin FC | 1:2 | ||||
| 4. Journée | 15.05.2022 | Real Salt Lake | - | Austin FC | 2:1 | |
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| 4. Journée | 19.05.2022 | Los Angeles FC | - | Austin FC | 1:2 | |
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| 7. Journée | 27.08.2022 | Austin FC | - | Los Angeles FC | 4:1 | ||||
| 8. Journée | 11.09.2022 | Seattle Sounders | - | Austin FC | 3:0 | |
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| 8. Journée | 18.09.2022 | Austin FC | - | Nashville SC | 1:1 | ||||
| 9. Journée | 09.10.2022 | Austin FC | - | Colorado Rapids | 1:1 |
Colombie