| 1. Journée | 21.03.2021 | Blooming | - | CD Guabirá | 0:1 |  |
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| 4. Journée | 11.04.2021 | CD Guabirá | - | Real Tomayapo | 0:2 | |
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| 5. Journée | 24.04.2021 | Club San José | - | CD Guabirá | 0:1 | ||||
| 6. Journée | 02.05.2021 | CD Guabirá | - | Real Santa Cruz | 1:0 | ||||
| 7. Journée | 09.05.2021 | Nacional Potosí | - | CD Guabirá | 2:1 |
Bolivie