| 8. Journée | 15.09.2021 | Alebrijes de Oaxaca | - | Mineros de Zacatecas | 2:1 |  |
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| 9. Journée | 24.09.2021 | Atlético Morelia | - | Alebrijes de Oaxaca | 1:0 | ||||
| 10. Journée | 30.09.2021 | Alebrijes de Oaxaca | - | Tapatío | 0:1 | ||||
| 11. Journée | 06.10.2021 | Venados FC | - | Alebrijes de Oaxaca | 1:1 | ||||
| 12. Journée | 13.10.2021 | Alebrijes de Oaxaca | - | TM Fútbol Club | 2:2 | ||||
| 13. Journée | 21.10.2021 | Club Celaya | - | Alebrijes de Oaxaca | 1:0 |
Colombie