| 1. Journée | 24.03.2022 | New York RB II | - | Louisville City FC | 0:2 | ||||
| 1. Journée | 27.03.2022 | Louisville City FC | - | Indy Eleven | 1:1 | ||||
| 2. Journée | 17.04.2022 | San Diego Loyal | - | Louisville City FC | 2:5 | ||||
| 2. Journée | 23.04.2022 | Charleston Battery | - | Louisville City FC | 1:1 |  |
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| 3. Journée | 01.05.2022 | Louisville City FC | - | Pittsburgh Riverhounds | 2:0 | ||||
| 3. Journée | 14.05.2022 | Los Angeles Galaxy II | - | Louisville City FC | 4:3 | |
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| 3. Journée | 22.05.2022 | Louisville City FC | - | Monterey Bay FC | 0:2 | ||||
| 5. Journée | 10.07.2022 | Louisville City FC | - | New York RB II | 6:0 | ||||
| 5. Journée | 17.07.2022 | Memphis 901 | - | Louisville City FC | 1:2 | ||||
| 6. Journée | 21.08.2022 | Detroit City FC | - | Louisville City FC | 0:1 | ||||
| 7. Journée | 01.09.2022 | Indy Eleven | - | Louisville City FC | 2:1 | ||||
| 7. Journée | 04.09.2022 | Louisville City FC | - | Sacramento Republic | 3:1 | ||||
| 7. Journée | 08.09.2022 | FC Tulsa | - | Louisville City FC | 2:2 | ||||
| 8. Journée | 02.10.2022 | Rio Grande Valley FC | - | Louisville City FC | 0:1 | |
Espagne